Keyword : "niche" » 2 results
The main tissues of mesenchymal stem / stromal cells (MSCs) are bone marrow (BM) and adipose tissue (AT). These cells together form a network of cells ranging from the stem cell to the progenitors to the differentiated cells that are osteoblasts, chondrocytes, perivascular cells and medullary adipocytes for bone marrow, CSMs and adipocytes, perivascular cells and fibroblasts for TA MSCs. In humans, the identities and microenvironments of stem cells and progenitors remain to be discovered.
Scientific objective :
The objectives of the group are therefore to characterize these subpopulations of CSM within the MO or TA in adult...
This theme was developed within the team on the basis of very innovative results showing that the stromal fraction of adipose tissue has a potential for hematopoietic regeneration. We have demonstrated that this hematopoietic activity of adipose tissue is based on the presence of an abundant population of hematopoietic stem/progenitor cells, which essentially produce myeloid cells within this tissue, but also in other organs, under physiological conditions or following tissue injury. An alteration of the hematopoietic activity of adipose tissue can lead to the development of metabolic diseases, which shows the crucial importance of this process in maintaining tissue...