Equipe 2 mast cells - Stromalab - Targeting the stroma to regenerate - Médecine régénératrice, thérapie cellulaire, cellules souches mésenchymateuses, tissu adipeux, moelle osseuse, réparation, régénération Regenerative medicine, cell therapy, mesenchymal stem cells, adipose tissue, bone marrow, repair, regeneration

Publications » Rapid and Efficient Production of Human Functional Mast Cells Through a Three-Dimensional Culture of Adipose Tissue-Derived Stromal Vascular Cells.

differentiation, mast cells, 3d culture, stromal vascular fraction, adipose tissue, cell culture, ASC

Rapid and Efficient Production of Human Functional Mast Cells Through a Three-Dimensional Culture of Adipose Tissue-Derived Stromal Vascular Cells.

Jenny Paupert, Eric Espinosa, Nicolas Cenac, Virginie Robert, Patrick Laharrague, Solène M Evrard, Louis Casteilla, Anne Lorsignol, Béatrice Cousin. Journal of immunology

Equipe 2 » Aim2 : Interaction MSC/Immunity

mast cells, macrophage, clinical trial, bone marrow, adipose tissue

Introduction : Mesenchymal stromal cells, due to their immunoregulatory properties, are used in many clinical trials to treat different disorders such as dysimmune and inflammatory diseases, hematopoietic stem cell transplantation and organ transplants. These immunosuppressive capacities of MSCs play a central role during tissue repair. Indeed, MSCs are sensors of the inflammatory environment, and therefore can modify macrophage functions (in particular MSCs can "switch" M1-pro-inflammatory macrophages in M2-anti-inflammatory macrophages). However, the interaction between MФ and MSCs and its effect on the MSC properties are poorly understood. Moreover, for a better use of these cells in clinic, we need to determine...