Stromalab - Targeting the stroma to regenerate Médecine régénératrice, thérapie cellulaire, cellules souches mésenchymateuses, tissu adipeux, moelle osseuse, réparation, régénération Regenerative medicine, cell therapy, mesenchymal stem cells, adipose tissue, bone marrow, repair, regeneration

Keyword : "macrophage" » 2 results

Publications » CD54-Mediated Interaction with Pro-inflammatory Macrophages Increases the Immunosuppressive Function of Human Mesenchymal Stromal Cells.

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Espagnolle N, Balguerie A, Arnaud E, Sensebé L, Varin A. Stem Cell Reports

Equipe 2 » Aim2 : Interaction MSC/Immunity

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Introduction :   Mesenchymal stromal cells, due to their immunoregulatory properties, are used in many clinical trials to treat different disorders such as dysimmune and inflammatory diseases, hematopoietic stem cell transplantation and organ transplants. These immunosuppressive capacities of MSCs play a central role during tissue repair. Indeed, MSCs are sensors of the inflammatory environment, and therefore can modify macrophage functions (in particular MSCs can "switch" M1-pro-inflammatory macrophages in M2-anti-inflammatory macrophages). However, the interaction between MФ and MSCs and its effect on the MSC properties are poorly understood. Moreover, for a better use of these cells in clinic, we need to determine...