Stromalab - Targeting the stroma to regenerate Médecine régénératrice, thérapie cellulaire, cellules souches mésenchymateuses, tissu adipeux, moelle osseuse, réparation, régénération Regenerative medicine, cell therapy, mesenchymal stem cells, adipose tissue, bone marrow, repair, regeneration

Keyword : "hypoxia" » 4 results

Publications » FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model.

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Gstalder C, Ader I*, Cuvillier O*. Mol Cancer Ther. *Co-corresponding authors

Equipe 2 » Aim 1 : Natives MSC and stemness

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Presentation : The main tissues of mesenchymal stem / stromal cells (MSCs) are bone marrow (BM) and adipose tissue (AT). These cells together form a network of cells ranging from the stem cell to the progenitors to the differentiated cells that are osteoblasts, chondrocytes, perivascular cells and medullary adipocytes for bone marrow,  CSMs and adipocytes, perivascular cells and fibroblasts for TA MSCs. In humans, the identities and microenvironments of stem cells and progenitors remain to be discovered.   Scientific objective : The objectives of the group are therefore to characterize these subpopulations of CSM within the MO or TA in adult...

Publications » Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer.

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Bouquerel P, Gstalder C, Müller D, Laurent J, Brizuela L, Sabbadini RA, Malavaud B, Pyronnet S, Martineau Y, Ader I*, Cuvillier O*. Oncogenesis. *Co-corresponding authors

Publications » Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer.

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Ader I, Gstalder C, Bouquerel P, Golzio M, Andrieu G, Zalvidea S, Richard S, Sabbadini RA, Malavaud B, Cuvillier O. Oncotarget.