Equipe 2 bone marrow - Stromalab - Targeting the stroma to regenerate - Médecine régénératrice, thérapie cellulaire, cellules souches mésenchymateuses, tissu adipeux, moelle osseuse, réparation, régénération Regenerative medicine, cell therapy, mesenchymal stem cells, adipose tissue, bone marrow, repair, regeneration

Publications » CD54-Mediated Interaction with Pro-inflammatory Macrophages Increases the Immunosuppressive Function of Human Mesenchymal Stromal Cells.

immunosuppression, macrophage, bone marrow, cell therapy, mesenchymal stem cells

Espagnolle N, Balguerie A, Arnaud E, Sensebé L, Varin A. Stem Cell Reports

Publications » Immuno-metabolism and adipose tissue: The key role of hematopoietic stem cells.

hematopoietic stem cell, metabolism, bone marrow, adipose tissue

Cousin B, Casteilla L, Laharrague P, Luche E, Lorsignol A, Cuminetti V, Paupert J. Biochimie.

Equipe 2 » Aim 1 : Natives MSC and stemness

Mesenchymal stromal cells, hypoxia, plasticity, 3d culture, modelling, transcriptome, niche, metabolism, bone marrow, adipose tissue, heterogeneity, mesenchymal stem cells

Presentation : The main tissues of mesenchymal stem / stromal cells (MSCs) are bone marrow (BM) and adipose tissue (AT). These cells together form a network of cells ranging from the stem cell to the progenitors to the differentiated cells that are osteoblasts, chondrocytes, perivascular cells and medullary adipocytes for bone marrow, CSMs and adipocytes, perivascular cells and fibroblasts for TA MSCs. In humans, the identities and microenvironments of stem cells and progenitors remain to be discovered. Scientific objective : The objectives of the group are therefore to characterize these subpopulations of CSM within the MO or TA in adult...

Equipe 2 » Aim2 : Interaction MSC/Immunity

mast cells, macrophage, clinical trial, bone marrow, adipose tissue

Introduction : Mesenchymal stromal cells, due to their immunoregulatory properties, are used in many clinical trials to treat different disorders such as dysimmune and inflammatory diseases, hematopoietic stem cell transplantation and organ transplants. These immunosuppressive capacities of MSCs play a central role during tissue repair. Indeed, MSCs are sensors of the inflammatory environment, and therefore can modify macrophage functions (in particular MSCs can "switch" M1-pro-inflammatory macrophages in M2-anti-inflammatory macrophages). However, the interaction between MФ and MSCs and its effect on the MSC properties are poorly understood. Moreover, for a better use of these cells in clinic, we need to determine...