Head : Pr. Louis CASTEILLA
Mesenchymal stromal cells, due to their immunoregulatory properties, are used in many clinical trials to treat different disorders such as dysimmune and inflammatory diseases, hematopoietic stem cell transplantation and organ transplants. These immunosuppressive capacities of MSCs play a central role during tissue repair. Indeed, MSCs are sensors of the inflammatory environment, and therefore can modify macrophage functions (in particular MSCs can “switch” M1-pro-inflammatory macrophages in M2-anti-inflammatory macrophages). However, the interaction between MФ and MSCs and its effect on the MSC properties are poorly understood.
Moreover, for a better use of these cells in clinic, we need to determine whether MSCs from different tissues have the same behavior in a pro-inflammatory microenvironment.
The other focus of the group, linked to the previous topic, is to determine the role of ASCs in the skin regeneration, in the angiogenesis and in the resolution of chronic inflammatory diseases through in vivo models (eg periodontitis).
Scientific objective :
- To understand the modes of communication between the innate immune cells (eg. macrophages, mast cells) and the MSCs (isolated from the bone marrow or from the adipose tissue)
- To study the consequences of the MSCs-macrophages cross-talk on the MSCs functions.
- To understand the role of ASCs in skin regeneration and angiogenesis via their immunosuppressive capacities and their potential to differentiate.
Expected health benefits :
Our work will help us to understand the MSCs functions to improve their use in clinic to treat inflammatory and dysummunitary disorders. The first field of their clinical application will be skin disorders such as burns and ulcers.