STROMALab Médecine régénératrice, thérapie cellulaire, cellules souches mésenchymateuses, tissu adipeux, moelle osseuse, réparation, régénération Regenerative medicine, cell therapy, mesenchymal stem cells, adipose tissue, bone marrow, repair, regeneration

Aim 2 : WAT hematopoiesis and tissue integrity

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Presentation :

This theme was developed within the team on the basis of very innovative results showing that the stromal fraction of adipose tissue has a potential for hematopoietic regeneration. We have demonstrated that this hematopoietic activity of adipose tissue is based on the presence of an abundant population of hematopoietic stem/progenitor cells, which essentially produce myeloid cells within this tissue, but also in other organs, under physiological conditions or following tissue injury. An alteration of the hematopoietic activity of adipose tissue can lead to the development of metabolic diseases, which shows the crucial importance of this process in maintaining tissue homeostasis. These original results suggest that adipose tissue constitutes an alternative source to bone marrow, of innate immune cells that could contribute to inter-organ dialogue.

 

Scientific Objective :

Our objective is to demonstrate that beyond metabolic and endocrine signals, adipose tissue is able of interacting with other organs through the production of myeloid cells that could participate in remodeling and/or regeneration processes in different tissues.

 

Expected Health Outcomes :

From a therapeutic point of view, the expected benefits concern regenerative medicine and the development of innovative therapies that would target hematopoietic stem cells in adipose tissue without altering medullary hematopoiesis.

 

Manpower :

  •        1 DR CNRS : Béatrice Cousin
  •        2 teacher-researchers : Anne Lorsignol, Laurent Guilleminault
  •        1 post-doctoral fellow : Virginie Gavioli
  •        1 technical support : Christophe Guissard (50%)

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