The objective of our sub-theme is to contribute to the understanding of the mechanisms that inhibit regeneration in adult mammals.
Scientific Objectives :
The objective is to identify, using adipose tissue as a model, the signals from the stroma and in particular from mesenchymal stromal cells (ASC), which may induce regeneration of tissues and/or organs and to determine how these cells could participate in regeneration. Particular attention is paid to the study of the cellular dynamics of adipose tissue and the involvement of metabolism in these processes.
Expected Health Outcomes :
From a therapeutic point of view, the expected benefits concern regenerative medicine and the development of innovative cellular and/or pharmacological therapies capable of inducing the regeneration of a complex tissue.
- 3 researchers CNRS : Audrey Carrière, Amandine Girousse, Marielle Ousset
- 1 researcher INSERM : Coralie Sengenès
- 4 teachers-researchers : Louis Casteilla, Cécile Dromard-Berthezène, Anne Galinier, Jenny Paupert
- 3 PhD students : Quentin Sastourne-Arrey, Lise Rabiller, Damien Lagarde
- 4 technical support : Emmanuelle Arnaud, Yannick Jeanson, Mireille André, Christophe Guissard