Stromalab - Targeting the stroma to regenerate Médecine régénératrice, thérapie cellulaire, cellules souches mésenchymateuses, tissu adipeux, moelle osseuse, réparation, régénération Regenerative medicine, cell therapy, mesenchymal stem cells, adipose tissue, bone marrow, repair, regeneration

Opioids inhibit tissue regeneration

 

figure papier regen opioidesIn most mammals, the scarring process is fast-paced but alters the normal functioning of the tissue, unlike regeneration. In a study published in August 2018 in Scientific Reports, a team from the StromaLab laboratory (UMR 1031 – UT3 Paul Sabatier/EFS/ENVT/Inserm/ERL CNRS 5311), shows that the painkillers currently used are leading tissue repair towards scar healing and not regeneration. These results question about the actual pain relief strategy.

Regeneration is a complex biological process that allows an organism to restore a damaged tissue close to its original state. While spectacular examples exist in nature, such as the salamander capable of re-forming an entire limb after its amputation, regeneration in adult mammals is an exceptional phenomenon. In the vast majority of cases, the repair of an organ following a massive injury leads to scar healing that will frequently be associated with functional loss. From an evolutionary point of view, the scarring process leads more quickly to the reconstitution of a barrier against subsequent aggressions compared to the regeneration process.

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