Stromalab - Targeting the stroma to regenerate Médecine régénératrice, thérapie cellulaire, cellules souches mésenchymateuses, tissu adipeux, moelle osseuse, réparation, régénération Regenerative medicine, cell therapy, mesenchymal stem cells, adipose tissue, bone marrow, repair, regeneration

Abnormal release of fat progenitors: when the fat is under pressure!

 

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The presence of ectopic adipocytes in the muscle is known to be detrimental to the metabolism. Until now it has been accepted that these fat cells came from the maturation of a local population of fat progenitors. This study published in Cell Reports shows that in mice in a context of caloric overload, subcutaneous adipose tissue abnormally releases adipose progenitors migrating to muscle, which participate in the formation of ectopic adipocytes and associated metabolic damage.

Adipose tissue has a remarkable plasticity that allows it to adapt to large variations in energy storage. This capacity, based on the increase in the size and number of adipocytes, is however limited and in a prolonged situation of energy imbalance it is frequent to observe an accumulation of lipids called “ectopic” because not associated with adipose tissue. This is particularly the case in skeletal muscle where, in addition to the appearance of small lipid droplets within the muscle fibres, real fat cells form between the muscle fibres and are associated with metabolic disorders such as insulin resistance.

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Opioids inhibit tissue regeneration

 

In most mammals, the scarring process is fast-paced but alters the normal functioning of the tissue, unlike regeneration. In a study published in August 2018 in Scientific Reports, a team from the StromaLab laboratory (UMR 1031 – UT3 Paul Sabatier/EFS/ENVT/Inserm/ERL CNRS 5311), shows that the painkillers currently used are leading tissue repair towards scar healing and not regeneration. These results question about the actual pain relief strategy.

Regeneration is a complex biological process that allows an organism to restore a damaged tissue close to its original state. While spectacular examples exist in nature, such as the salamander capable of re-forming an entire limb after its amputation, regeneration in adult mammals is an exceptional phenomenon. In the vast majority of cases, the repair of an organ following a massive injury leads to scar healing that will frequently be associated with functional loss. From an evolutionary point of view, the scarring process leads more quickly to the reconstitution of a barrier against subsequent aggressions compared to the regeneration process.

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