Stromalab - Targeting the stroma to regenerate Médecine régénératrice, thérapie cellulaire, cellules souches mésenchymateuses, tissu adipeux, moelle osseuse, réparation, régénération Regenerative medicine, cell therapy, mesenchymal stem cells, adipose tissue, bone marrow, repair, regeneration

Archive des publications


Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure.

Carrière A, Jeanson Y, Berger-Müller S, André M, Chenouard V, Arnaud E, Barreau C, Walther R, Galinier A, Wdziekonski B, Villageois P, Louche K, Collas P, Moro C, Dani C, Villarroya F, Casteilla L.

Diabetes. 2014 Oct;63(10):3253-65. doi: 10.2337/db13-1885. Epub 2014 May 1.


Mouse adipose tissue stromal cells give rise to skeletal and cardiomyogenic cell sub-populations.

Dromard C, Barreau C, André M, Berger-Müller S, Casteilla L, Planat-Benard V.

Front Cell Dev Biol. 2014 Aug 25;2:42. doi: 10.3389/fcell.2014.00042. eCollection 2014.


Concise review: mesenchymal stromal cells used for periodontal regeneration: a systematic review.

Monsarrat P, Vergnes JN, Nabet C, Sixou M, Snead ML, Planat-Bénard V, Casteilla L, Kémoun P.

Stem Cells Transl Med. 2014 Jun;3(6):768-74. doi: 10.5966/sctm.2013-0183. Epub 2014 Apr 17. Review.


Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart.

Turkieh A, Caubère C, Barutaut M, Desmoulin F, Harmancey R, Galinier M, Berry M, Dambrin C, Polidori C, Casteilla L, Koukoui F, Rouet P, Smih F.

J Clin Invest. 2014 May;124(5):2277-86. doi: 10.1172/JCI74668. Epub 2014 Apr 17.


A clinical scalable cryopreservation method of adipose tissue for reconstructive surgery assessed by stromal vascular fraction and mice studies.

Chaput B, Orio J, Garrido I, De Bonnecaze G, Espagnolle N, Gadelorge M, Chavoin JP, Grolleau-Raoux JL, Casteilla L, Planat V, Bourin P.

Plast Reconstr Surg. 2014 Apr;133(4):815-26. doi: 10.1097/PRS.0000000000000051.


Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia.

Bura A, Planat-Benard V, Bourin P, Silvestre JS, Gross F, Grolleau JL, Saint-Lebese B, Peyrafitte JAFleury S, Gadelorge M, Taurand M, Dupuis-Coronas S, Leobon B, Casteilla L.

Cytotherapy. 2014 Feb;16(2):245-57. doi: 10.1016/j.jcyt.2013.11.011.

PMID: 24438903


Hypothalamic eIF2 Signaling Regulates Food Intake.

Maurin AC, Benani A, Lorsignol A, Brenachot X, Parry L, Carraro V, Guissard C, Averous J, Jousse C, Bruhat A, Chaveroux C, B’chir W, Muranishi Y, Ron D, Pénicaud L, Fafournoux P.

Cell Rep. 2014 Feb 13;6(3):438-44. doi: 10.1016/j.celrep.2014.01.006. Epub 2014 Jan 30.



Visceral white fat remodelling contributes to intermittent hypoxia-induced atherogenesis.

Poulain L, Thomas A, Rieusset J, Casteilla L, Levy P, Arnaud C, Dematteis M.

Eur Respir J. 2014 Feb;43(2):513-22. doi: 10.1183/09031936.00019913. Epub 2013 Sep 26.



Cell therapy for bone repair.

Rosset P, Deschaseaux F, Layrolle P.

Orthop Traumatol Surg Res. 2014 Jan 7. pii: S1877-0568(13)00279-X. doi: 10.1016/j.otsr.2013.11.010. [Epub ahead of print]



CD146 expression on mesenchymal stem cells is associated with their vascular smooth muscle commitment.

Espagnolle N, Guilloton F, Deschaseaux F, Gadelorge M, Sensébé L, Bourin P.

J Cell Mol Med. 2014 Jan;18(1):104-14. doi: 10.1111/jcmm.12168. Epub 2013 Nov 4.



Long-term functional benefits of epicardial patches as cell carriers.

Hamdi H, Planat-Benard V, Bel A, Neamatalla H, Saccenti L, Calderon D, Bellamy V, Bon M, Perrier MC, Mandet C, Bruneval P, Casteilla L, Hagège AA, Pucéat M, Agbulut O, Menasché P.

Cell Transplant. 2014;23(1):87-96. doi: 10.3727/096368912X658836. Epub 2012 Nov 1.




Ex vivo microperfusion system of the adipose organ: a new approach to studying the mobilization of adipose cell populations.

Gil-Ortega M, Fernández-Alfonso MS, Somoza B, Casteilla L, Sengenès C.

Int J Obes (Lond). 2013 Dec 20. doi: 10.1038/ijo.2013.243. [Epub ahead of print]



Differentiation of human induced pluripotent stem cells into brown and white adipocytes: Role of Pax3.

Mohsen-Kanson T, Hafner AL, Wdziekonski B, Takashima Y, Villageois P, Carrière A, Svensson M, Bagnis C, Chignon-Sicard B, Svensson PA, CasteillaL, Smith A, Dani C.

Stem Cells. 2013 Dec 3. doi: 10.1002/stem.1607. [Epub ahead of print]



Beyond genetic stability of mesenchymal stromal cells.

Sensebé L.

Cytotherapy. 2013 Nov;15(11):1307-8. doi: 10.1016/j.jcyt.2013.09.001. No abstract available.



Concise review: combining human leukocyte antigen G and mesenchymal stem cells for immunosuppressant biotherapy.

Naji A, Rouas-Freiss N, Durrbach A, Carosella ED, Sensébé L, Deschaseaux F.

Stem Cells. 2013 Nov;31(11):2296-303. doi: 10.1002/stem.1494.



Biodistribution of Mesenchymal Stem/Stromal Cells in a Preclinical Setting.

Sensebé L, Fleury-Cappellesso S.

Stem Cells Int. 2013;2013:678063. Epub 2013 Oct 10. Review.



Age-related changes in the features of porcine adult stem cells isolated from adipose tissue and skeletal muscle.

Perruchot MH, Lefaucheur L, Barreau C, Casteilla L, Louveau I.

Am J Physiol Cell Physiol. 2013 Oct 1;305(7):C728-38. doi: 10.1152/ajpcell.00151.2013. Epub 2013 Jul 17.



Efficacy of epicardially delivered adipose stroma cell sheets in dilated cardiomyopathy.

Hamdi H, Boitard SE, Planat-Benard V, Pouly J, Neamatalla H, Joanne P, Perier MC, Bellamy V, Casteilla L, Li Z, Hagège AA, Mericskay M, Menasché P, Agbulut O.

Cardiovasc Res. 2013 Sep 1;99(4):640-7. doi: 10.1093/cvr/cvt149. Epub 2013 Jun 13.



Immunological characterization of multipotent mesenchymal stromal cells–The International Society for Cellular Therapy (ISCT) working proposal.

Krampera M, Galipeau J, Shi Y, Tarte K, Sensebe L; MSC Committee of the International Society for Cellular Therapy (ISCT).

Cytotherapy. 2013 Sep;15(9):1054-61. doi: 10.1016/j.jcyt.2013.02.010. Epub 2013 Apr 17.



Fatty acid transporter CD36 mediates hypothalamic effect of fatty acids on food intake in rats.

Moullé VS, Le Foll C, Philippe E, Kassis N, Rouch C, Marsollier N, Bui LC, Guissard C, Dairou J, Lorsignol A, Pénicaud L, Levin BE, Cruciani-Guglielmacci C, Magnan C.

PLoS One. 2013 Sep 6;8(9):e74021. doi: 10.1371/journal.pone.0074021. eCollection 2013.



[Recruitment and activation of brown and/or BRITE adipocytes : potential therapeutic against metabolic diseases].

Carrière A, Jeanson Y, Cousin B, Arnaud E, Casteilla L.

Med Sci (Paris). 2013 Aug-Sep;29(8-9):729-35. doi: 10.1051/medsci/2013298011. Epub 2013 Sep 5. Review. French.



CD200R/CD200 inhibits osteoclastogenesis: new mechanism of osteoclast control by mesenchymal stem cells in human.

Varin A, Pontikoglou C, Labat E, Deschaseaux F, Sensebé L.

PLoS One. 2013 Aug 5;8(8):e72831. doi: 10.1371/journal.pone.0072831. Print 2013.



Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue.

Deschaseaux F, Gaillard J, Langonné A, Chauveau C, Naji A, Bouacida A, Rosset P, Heymann D, De Pinieux G, Rouas-Freiss N, Sensébé L.

FASEB J. 2013 Aug;27(8):2977-87. doi: 10.1096/fj.13-227264. Epub 2013 Apr 16.



Native adipose stromal cells egress from adipose tissue in vivo: evidence during lymph node activation.

Gil-Ortega M, Garidou L, Barreau C, Maumus M, Breasson L, Tavernier G, García-Prieto CF, Bouloumié A, Casteilla L, Sengenès C.

Stem Cells. 2013 Jul;31(7):1309-20. doi: 10.1002/stem.1375.



Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at the onset of metabolic diseases through a CD14-dependent mechanism.

Luche E, Cousin B, Garidou L, Serino M, Waget A, Barreau C, André M, Valet P, Courtney M, Casteilla L, Burcelin R.

Mol Metab. 2013 Jul 4;2(3):281-91. doi: 10.1016/j.molmet.2013.06.005. eCollection 2013.



Long-term detection of human adipose-derived mesenchymal stem cells after intraarticular injection in SCID mice.

Toupet K, Maumus M, Peyrafitte JA, Bourin P, van Lent PL, Ferreira R, Orsetti B, Pirot N, Casteilla L, Jorgensen C, Noël D.

Arthritis Rheum. 2013 Jul;65(7):1786-94. doi: 10.1002/art.37960.



MSCs: science and trials.

Phinney DG, Galipeau J, Krampera M, Martin I, Shi Y, Sensebe L.

Nat Med. 2013 Jul;19(7):812. doi: 10.1038/nm.3220. No abstract available.



Production of mesenchymal stromal/stem cells according to good manufacturing practices: a review.

Sensebé L, Gadelorge M, Fleury-Cappellesso S.

Stem Cell Res Ther. 2013 Jun 7;4(3):66. [Epub ahead of print]



Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT).

Bourin P, Bunnell BA, Casteilla L, Dominici M, Katz AJ, March KL, Redl H, Rubin JP, Yoshimura K, Gimble JM.

Cytotherapy. 2013 Jun;15(6):641-8. doi: 10.1016/j.jcyt.2013.02.006. Epub 2013 Apr 6.



Comparative study of the osteogenic ability of four different ceramic constructs in an ectopic large animal model.

Viateau V, Manassero M, Sensébé L, Langonné A, Marchat D, Logeart-Avramoglou D, Petite H, Bensidhoum M.

J Tissue Eng Regen Med. 2013 Jun 20. doi: 10.1002/term.1782. [Epub ahead of print]

PMID: 23784976


Clinical-grade mesenchymal stromal cells produced under various good manufacturing practice processes differ in their immunomodulatory properties: standardization of immune quality controls.

Menard C, Pacelli L, Bassi G, Dulong J, Bifari F, Bezier I, Zanoncello J, Ricciardi M, Latour M, Bourin P, Schrezenmeier H, Sensebé L, Tarte K, Krampera M.

Stem Cells Dev. 2013 Jun 15;22(12):1789-801. doi: 10.1089/scd.2012.0594. Epub 2013 Feb 25.



Harnessing the beneficial properties of adipogenic microbes for improving human health.

Dhurandhar NV, Geurts L, Atkinson RL, Casteilla L, Clement K, Gerard P, Vijay-Kumar M, Nam JH, Nieuwdorp M, Trovato G, Sørensen TI, Vidal-Puig A, Cani PD.

Obes Rev. 2013 May 12. doi: 10.1111/obr.12045. [Epub ahead of print]



Influence of untranslated regions on retroviral mRNA transfer and expression.

Prel A, Sensébé L, Pagès JC.

BMC Biotechnol. 2013 Apr 16;13:35. doi: 10.1186/1472-6750-13-35.



Aging-related decrease of human ASC angiogenic potential is reversed by hypoxia preconditioning through ROS production.

De Barros S, Dehez S, Arnaud E, Barreau C, Cazavet A, Perez G, Galinier A, Casteilla L, Planat-Bénard V.

Mol Ther. 2013 Feb;21(2):399-408. doi: 10.1038/mt.2012.213. Epub 2012 Oct 16.



Mesenchymal stromal cells: misconceptions and evolving concepts.

Phinney DG, Sensebé L.

Cytotherapy. 2013 Feb;15(2):140-5. doi: 10.1016/j.jcyt.2012.11.005. Review.



Donor selection and release criteria of cellular therapy products.

Eichler H, Schrezenmeier H, Schallmoser K, Strunk D, Nystedt J, Kaartinen T, Korhonen M, Fleury-Cappellesso S, Sensebé L, Bönig H, Rebulla P, Giordano R, Lecchi L, Takanashi M, Watt SM, Austin EB, Guttridge M, McLaughlin LS, Panzer S, Reesink HW.

Vox Sang. 2013 Jan;104(1):67-91. doi: 10.1111/j.1423-0410.2012.01619.x. No abstract available.

PMID :23252690



In situ production of innate immune cells in murine white adipose tissue.

Poglio S, De Toni F, Lewandowski D, Minot A, Arnaud E, Barroca V, Laharrague P, Casteilla L, Cousin B.

Blood. 2012 Dec 13;120(25):4952-62. doi: 10.1182/blood-2012-01-406959. Epub 2012 Oct 15.



Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis.

ter Huurne M, Schelbergen R, Blattes R, Blom A, de Munter W, Grevers LC, Jeanson J, Noël D, Casteilla L, Jorgensen C, van den Berg W, van Lent PL.

Arthritis Rheum. 2012 Nov;64(11):3604-13. doi: 10.1002/art.34626.



Pericyte-like progenitors show high immaturity and engraftment potential as compared with mesenchymal stem cells.

Bouacida A, Rosset P, Trichet V, Guilloton F, Espagnolle N, Cordonier T, Heymann D, Layrolle P, Sensébé L, Deschaseaux F.

PLoS One. 2012;7(11):e48648. doi: 10.1371/journal.pone.0048648. Epub 2012 Nov 7.



GMP-compliant isolation and expansion of bone marrow-derived MSCs in the closed, automated device quantum cell expansion system.

Rojewski MT, Fekete N, Baila S, Nguyen K, Fürst D, Antwiler D, Dausend J, Kreja L, Ignatius A, Sensebé L, Schrezenmeier H.

Cell Transplant. 2013;22(11):1981-2000. doi: 10.3727/096368912X657990. Epub 2012 Oct 25.



Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice.

Benani A, Hryhorczuk C, Gouazé A, Fioramonti X, Brenachot X, Guissard C, Krezymon A, Duparc T, Colom A, Nédélec E, Rigault C, Lemoine A, Gascuel J, Gerardy-Schahn R, Valet P, Knauf C, Lorsignol A, Pénicaud L.

J Neurosci. 2012 Aug 29;32(35):11970-9. doi: 10.1523/JNEUROSCI.0624-12.2012.



UCP1 as a water/proton co-transporter.

Casteilla L, Devin A, Salin B, Averet N, Rigoulet M.

Mitochondrion. 2012 Jul;12(4):480-1. doi: 10.1016/j.mito.2012.04.003. Epub 2012 May 5. No abstract available.



Pro-inflammatory phospholipid arachidonic acid/eicosapentaenoic acid ratio of dysmetabolic severely obese women.

Caspar-Bauguil S, Fioroni A, Galinier A, Allenbach S, Pujol MC, Salvayre R, Cartier A, Lemieux I, Richard D, Biron S, Marceau P, Casteilla L, Pénicaud L, Mauriège P.

Obes Surg. 2012 Jun;22(6):935-44. doi: 10.1007/s11695-012-0633-0.



Osteoblastic differentiation and potent osteogenicity of three-dimensional hBMSC-BCP particle constructs.

Cordonnier T, Langonné A, Corre P, Renaud A, Sensebé L, Rosset P, Layrolle P, Sohier J.

J Tissue Eng Regen Med. 2012 Jun 11. doi: 10.1002/term.1529. [Epub ahead of print]



cAMP-induced mitochondrial compartment biogenesis: role of glutathione redox state.

Yoboue ED, Augier E, Galinier A, Blancard C, Pinson B, Casteilla L, Rigoulet M, Devin A.

J Biol Chem. 2012 Apr 27;287(18):14569-78. doi: 10.1074/jbc.M111.302786. Epub 2012 Mar 6.



Immune response to human embryonic stem cell-derived cardiac progenitors and adipose-derived stromal cells.

Calderon D, Planat-Benard V, Bellamy V, Vanneaux V, Kuhn C, Peyrard S, Larghero J, Desnos M, Casteilla L, Pucéat M, Menasché P, Chatenoud L.

J Cell Mol Med. 2012 Jul;16(7):1544-52. doi: 10.1111/j.1582-4934.2011.01435.x.



Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle.

Russell AP, Crisan M, Léger B, Corselli M, McAinch AJ, O’Brien PE, Cameron-Smith D, Péault B, Casteilla L, Giacobino JP.

Int J Obes (Lond). 2012 Jan;36(1):155-8. doi: 10.1038/ijo.2011.85. Epub 2011 Apr 26.



Limited acquisition of chromosomal aberrations in human adult mesenchymal stromal cells.

Sensebé L, Tarte K, Galipeau J, Krampera M, Martin I, Phinney DG, Shi Y; MSC Committee of the International Society for Cellular Therapy.

Cell Stem Cell. 2012 Jan 6;10(1):9-10; author reply 10-1. doi: 10.1016/j.stem.2011.12.005. No abstract available.




Control of mitochondrial volume by mitochondrial metabolic water.

Casteilla L, Devin A, Carriere A, Salin B, Schaeffer J, Rigoulet M.

Mitochondrion. 2011 Nov;11(6):862-6. doi: 10.1016/j.mito.2011.06.008. Epub 2011 Jul 1.



Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation.

Pontikoglou C, Deschaseaux F, Sensebé L, Papadaki HA.

Stem Cell Rev. 2011 Sep;7(3):569-89. doi: 10.1007/s12015-011-9228-8. Review.



Epicardial adipose stem cell sheets results in greater post-infarction survival than intramyocardial injections.

Hamdi H, Planat-Benard V, Bel A, Puymirat E, Geha R, Pidial L, Nematalla H, Bellamy V, Bouaziz P, Peyrard S, Casteilla L, Bruneval P, Hagège AA, Agbulut O, Menasché P.

Cardiovasc Res. 2011 Aug 1;91(3):483-91. doi: 10.1093/cvr/cvr099. Epub 2011 May 12.



Adipose-derived stromal cells: Their identity and uses in clinical trials, an update.

Casteilla L, Planat-Benard V, Laharrague P, Cousin B.

World J Stem Cells. 2011 Apr 26;3(4):25-33. doi: 10.4252/wjsc.v3.i4.25.

PMID: 21607134


[Mesenchymal stem cells – The challenge of a good therapeutic product].

Sensebé L, Bourin P.

Med Sci (Paris). 2011 Mar;27(3):297-302. doi: 10.1051/medsci/2011273297. Epub 2011 Mar 30. French.



Phases I-III Clinical Trials Using Adult Stem Cells.

Gimble JM, Bunnell BA, Casteilla L, Jung JS, Yoshimura K.

Stem Cells Int. 2011 Feb 23;2010:604713. doi: 10.4061/2010/604713. No abstract available.



[Human mesenchymal stem cell biology].

Charbord P, Casteilla L.

Med Sci (Paris). 2011 Mar;27(3):261-7. doi: 10.1051/medsci/2011273261. Epub 2011 Mar 30. French.



[Use of adipose tissue in regenerative medicine].

Casteilla L, Planat-Benard V, Bourin P, Laharrague P, Cousin B.

Transfus Clin Biol. 2011 Apr;18(2):124-8. doi: 10.1016/j.tracli.2011.01.008. Epub 2011 Mar 11. Review. French.



Human adipose-derived stromal cells efficiently support hematopoiesis in vitro and in vivo: a key step for therapeutic studies.

De Toni F, Poglio S, Youcef AB, Cousin B, Pflumio F, Bourin P, Casteilla L, Laharrague P.

Stem Cells Dev. 2011 Dec;20(12):2127-38. doi: 10.1089/scd.2011.0044. Epub 2011 Apr 13.



Native human adipose stromal cells: localization, morphology and phenotype.

Maumus M, Peyrafitte JA, D’Angelo R, Fournier-Wirth C, Bouloumié A, CasteillaL, Sengenès C, Bourin P.

Int J Obes (Lond). 2011 Sep;35(9):1141-53. doi: 10.1038/ijo.2010.269. Epub 2011 Jan 25.



Human adipose derived stroma/stem cells grow in serum-free medium as floating spheres.

Dromard C, Bourin P, André M, De Barros S, Casteilla L, Planat-Benard V.

Exp Cell Res. 2011 Apr 1;317(6):770-80. doi: 10.1016/j.yexcr.2011.01.001. Epub 2011 Jan 19.



Effects of a high-fat diet on energy metabolism and ROS production in rat liver.

Vial G, Dubouchaud H, Couturier K, Cottet-Rousselle C, Taleux N, Athias A, Galinier A, Casteilla L, Leverve XM.

J Hepatol. 2011 Feb;54(2):348-56. doi: 10.1016/j.jhep.2010.06.044. Epub 2010 Sep 7.



Coenzyme Q as an antiadipogenic factor.

Bour S, Carmona MC, Galinier A, Caspar-Bauguil S, Van Gaal L, Staels B, Pénicaud L, Casteilla L.

Antioxid Redox Signal. 2011 Feb 1;14(3):403-13. doi: 10.1089/ars.2010.3350. Epub 2010 Nov 23.



Endothelial and cardiac regeneration from adipose tissues.

Casteilla L, Planat-Bénard V, Dehez S, De Barros S, Barreau C, André M.

Methods Mol Biol. 2011;702:269-87. doi: 10.1007/978-1-61737-960-4_20. Review.



Balancing mitochondrial redox signaling: a key point in metabolic regulation.

Leloup C, Casteilla L, Carrière A, Galinier A, Benani A, Carneiro L, Pénicaud L.

Antioxid Redox Signal. 2011 Feb 1;14(3):519-30. doi: 10.1089/ars.2010.3424. Review.



Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation.

Pontikoglou C, Deschaseaux F, Sensebé L, Papadaki HA.

Stem Cell Rev. 2011 Sep;7(3):569-89. doi: 10.1007/s12015-011-9228-8. Review.



Good manufacturing practices production of mesenchymal stem/stromal cells.

Sensebé L, Bourin P, Tarte K.

Hum Gene Ther. 2011 Jan;22(1):19-26. doi: 10.1089/hum.2010.197. Epub 2010 Dec 19. Review.



Consistent osteoblastic differentiation of human mesenchymal stem cells with bone morphogenetic protein 4 and low serum.

Cordonnier T, Langonné A, Sohier J, Layrolle P, Rosset P, Sensébé L, Deschaseaux F.

Tissue Eng Part C Methods. 2011 Mar;17(3):249-59. doi: 10.1089/ten.TEC.2010.0387. Epub 2010 Nov 4.