The regeneration of tissues and organs is a major cognitive and medical implications. Our goal is to understand some of the underlying mechanisms to improve / restore regenerative capacity in the adult mammals.
In adult animals, the maintenance of tissue integrity is enabled by a basal and permanent turnover of cells. This turn-over will be activated following tissue injury and is naturally impaired during aging that causes progressive degeneration of functional tissues and organs that appears irreversible. However, recent findings show that the regeneration of a complex organ such as aging may be reversible including in adult mammals.
Tissue integrity as its recovery following an injury involves regardless tissues several determinants including an essential local actor: the stroma. The importance of the stroma has been demonstrated through the work on hematopoiesis as normal as pathological. This stroma can be designed as a functional identity generically containing adult stem cells, i.e. mesenchymal stem cells (MSCs) that combine stemness and supportive functions.
The objective of our institute is to understand and decipher how stromal cells and particularly the MSC, one of the most known adult stem cells and already used in regenrative medicine, are involved in tissue homeostasis and promote repair / regeneration processes. We are particularly interested in the stroma and cellular components in bone marrow and adipose tissue. Bone marrow is one of the best known tissues can be considered as the tissue model. Adipose tissue, well-known for their involvement in obesity and metabolic diseases, are used in restorative and reconstructive medicine for long time. Many studies including ours have shown that these tissues contained a very large population of cells equivalent to the MSC, i.e. ASC. So we were the first in the world to describe the angiogenic potential of these cells, to adapt to their culture process for therapeutic uses and to test their potential in a therapeutic trial.
Our aims are:
- identify and characterize cell populations subsets of stem or stromal cells present in the stroma,
- better characterize and compare the features of native or cultivated MSC under physiological or pathological conditions characterized by a breakdown in tissue homeostasis,
- Examine how these tissues can be used as physiological reservoirs of adult stem regenerative cells,
- Studying the therapeutic uses of MSC/ASC in regenerative medicine.