28 September 2016
A post-doc position is now opened in STROMALab Institute, Toulouse, France, in the team “Adipose Tissue Plasticity”, aiming at studying the cellular dynamics in tissue repair/regeneration in adult mammals in vivo.
Academic context: This position funded by ANR is part of collaboration between two research groups: “Adipose Tissue Hematopoiesis and Tissue Integrity”, led by Beatrice Cousin within STROMALab in Toulouse (www.stromalab.com) and “Regenerative Therapies For Cardiac And Vascular Diseases” led by Jean-Sebastien Silvestre in Paris Cardiovascular Research Center (http://silvestrelab.weebly.com/).
Scientific context: Emerging evidences suggest that myeloid-derived cells may provide the necessary signals to drive tissue remodeling after injury. The classical paradigm indicates that these cells mainly derive from genuine hematopoietic progenitors residing in the bone marrow. However, we published several original reports showing that in addition to the bone marrow, adipose tissue constitutes an alternative source of innate immune cells that may contribute to inter-organ dialogue, and participate to tissue homeostasis and repair/regeneration processes (Poglio et al., Stem Cell, 2010; Blood 2012; Luche et al. J Cell Physiol, 2015; Ngkelo et al., J Exp Med. 2016; Luche et al., in revision).
Project Objectives: This project, based on strong preliminary data, is to demonstrate a major conceptual breakthrough, by establishing the proof of concept of an intrinsic crosstalk between adipose tissue-derived myeloid cells and the cardiac homeostasis and repair. It combines in vivo, cellular and molecular approaches, to bring new insights in the comprehension of cellular mechanisms of cardiac remodeling after myocardial infarction in metabolic diseases. The project is expected to provide significant advances in basic life science, regarding to a better understanding of integrated physiology, and inter-organ communication based on mouse and human cells. On a cognitive point of view, this project will also bring major input in the molecular mechanisms of action of adipose tissue hematopoietic stem/progenitor cells in repair processes.
Profile: We are looking for a candidate with a strong background and expertise in physiology and/or cell biology, immunology, and flow cytometry. Experience in metabolism is preferred, but not necessary. Highly motivated candidates with interests in the fields of cellular dynamics, inter-organ communication, regenerative medicine and developmental biology are welcome to apply. The successful candidate will join a small, collaborative team and benefit from excellent scientific environment within the Toulouse Oncopole, state of art research facilities, and expertise in stem cell biology, flow cytometry, imaging and regenerative medicine.
Requirement: Ph.D. in physiology, cell biology, immunology or developmental biology • Experience in multicolor flow cytometry, cell sorting, mouse models and previous work with tissue resident cell populations is required • Familiarity with metabolism is preferred, but not required.
Administrative aspects: The post-doctoral position is funded for 2 years (Gross salary, depending on experience: ~ 30 to 40 000 €/year; Net salary, including social security: ~ 24 to 34 000 €/year). The employer is the Centre National de la Recherche Scientifique (www.cnrs.fr), the largest fundamental research organization in Europe. Position will be open until filled, start date flexible between October 2016 and January 2017.
Applicants should submit curriculum vitae, brief description of research accomplishments and career goals, list of publications (published and “in preparation”), and the names of three references into a single document to Beatrice Cousin (firstname.lastname@example.org).